ABC has also axed The River, GCB, and Missing, TV Line reports.
Created by Jack Orman (ER) and based around the iconic international airline, the show followed the lives of a group of pilots and air hostesses in 1963 and began airing in the UK on BBC Two last November.
The cast included Christina Ricci (Sleepy Hollow), Mike Vogel (Cloverfield), Kelli Garner (Buffy the Vampire Slayer), Margot Robbie (Neighbours) and Michael Mosley (Scrubs).
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Watch the Pan Am launch trailer…