Marijuana has been proven to affect sperm quality and sperm count, but there is no evidence that shows that marijuana causes birth defects. In an embodiment, the substituted tetracycline compound is a substituted tetracycline (e.g., generally, wherein R 4 is NR 4′R 4″, R 4′ and R 4″ are methyl, R 5 is hydrogen and X is CR 6R 6′, wherein R 6 is methyl and R 6′ is hydroxy); substituted doxycycline (e.g., wherein R 4 is NR 4′R 4″, R 4′ and R 4″ are methyl, R 5 is hydroxyl and X is CR 6R 6′, wherein R 6 is methyl and R 6′ is hydrogen); substituted minocycline (e.g., wherein R 4 is NR 4′R 4″, R 4′ and R 4″ are methyl; R 5 is hydrogen and X is CR 6R 6′ wherein R 6 and R 6′ are hydrogen atoms and R 7 is dimethylamino) or substituted sancycline (wherein R 4 is NR 4′R 4″, R 4′ and R 4″ are methyl; R 5 is hydrogen and X is CR 6R 6′ wherein R 6 and R 6′ are hydrogen atoms).
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